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出生体重与身高发育之间的关联是否独立于种族和社会经济因素的混杂效应?

Is the association between birthweight and height attainment independent of the confounding effect of ethnic and socioeconomic factors?

作者信息

Seidman D S, Gale R, Stevenson D K, Laor A, Bettane P A, Danon Y L

机构信息

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

出版信息

Isr J Med Sci. 1993 Dec;29(12):772-6.

PMID:8300385
Abstract

The association between birthweight and body height attainment at 17 years of age was investigated by studying a sample of 30,083 subjects born in Jerusalem between 1964 and 1971. Birthweights obtained from the computerized records of the Jerusalem Perinatal Study were matched with demographic and medical examination results available from the military draft boards. Linear regression models for standing height by birthweight were fitted for the data in order to adjust for the possible confounding effect of ethnic origin, socioeconomic status (as determined by parental education level), birth order and maternal age. Separate models were constructed for each sex. A significant (P < 0.0001) linear increase in standing height by birthweight of 3.33 cm/1,000 g was observed for the males (mean +/- SE height 174.5 +/- 0.1 cm) and 2.85 cm/1,000 g for the females (mean +/- SE height 163.5 +/- 0.1 cm). This positive linear association between body height at 17 years of age and birthweight was also demonstrated after stratification according to various categories of social class and ethnic origin. Adult body height was thus found to be strongly related to birthweight in both sexes, regardless of ethnic and socioeconomic influences.

摘要

通过对1964年至1971年在耶路撒冷出生的30083名受试者进行抽样研究,调查了出生体重与17岁时身高发育之间的关联。从耶路撒冷围产期研究的计算机记录中获取的出生体重与征兵委员会提供的人口统计学和医学检查结果进行了匹配。为数据拟合了出生体重与身高的线性回归模型,以调整种族、社会经济地位(由父母教育水平决定)、出生顺序和母亲年龄可能产生的混杂效应。针对每种性别构建了单独的模型。观察到男性出生体重每增加1000克,身高显著线性增加3.33厘米(平均±标准误身高174.5±0.1厘米),女性为2.85厘米/1000克(平均±标准误身高163.5±0.1厘米)(P<0.0001)。根据不同社会阶层和种族类别进行分层后,也证实了17岁时身高与出生体重之间的这种正线性关联。因此发现,无论种族和社会经济影响如何,成年身高在男女两性中都与出生体重密切相关。

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