Jelenkovic Aline, Yokoyama Yoshie, Sund Reijo, Hur Yoon-Mi, Harris Jennifer R, Brandt Ingunn, Nilsen Thomas Sevenius, Ooki Syuichi, Ullemar Vilhelmina, Almqvist Catarina, Magnusson Patrik K E, Saudino Kimberly J, Stazi Maria A, Fagnani Corrado, Brescianini Sonia, Nelson Tracy L, Whitfield Keith E, Knafo-Noam Ariel, Mankuta David, Abramson Lior, Cutler Tessa L, Hopper John L, Llewellyn Clare H, Fisher Abigail, Corley Robin P, Huibregtse Brooke M, Derom Catherine A, Vlietinck Robert F, Bjerregaard-Andersen Morten, Beck-Nielsen Henning, Sodemann Morten, Krueger Robert F, McGue Matt, Pahlen Shandell, Alexandra Burt S, Klump Kelly L, Dubois Lise, Boivin Michel, Brendgen Mara, Dionne Ginette, Vitaro Frank, Willemsen Gonneke, Bartels Meike, van Beijsterveld Catharina E M, Craig Jeffrey M, Saffery Richard, Rasmussen Finn, Tynelius Per, Heikkilä Kauko, Pietiläinen Kirsi H, Bayasgalan Gombojav, Narandalai Danshiitsoodol, Haworth Claire M A, Plomin Robert, Ji Fuling, Ning Feng, Pang Zengchang, Rebato Esther, Tarnoki Adam D, Tarnoki David L, Kim Jina, Lee Jooyeon, Lee Sooji, Sung Joohon, Loos Ruth J F, Boomsma Dorret I, Sørensen Thorkild I A, Kaprio Jaakko, Silventoinen Karri
Department of Social Research, University of Helsinki, Helsinki, Finland; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Department of Public Health Nursing, Osaka City University, Osaka, Japan.
Early Hum Dev. 2018 May;120:53-60. doi: 10.1016/j.earlhumdev.2018.04.004. Epub 2018 Apr 12.
There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment.
To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.
This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses.
Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length.
Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
有证据表明出生时的体型与成年后的身高呈正相关，但尚不清楚这是由遗传因素还是子宫内环境所导致。
分析单卵和双卵双胞胎从婴儿期到成年期出生体重、身长和体重指数与身高的关联，以深入了解遗传和个体特异性环境因素的作用。
本研究基于17个国家28个双胞胎队列的数据。汇总数据包括41,852对完整双胞胎（55%为单卵双胞胎，45%为同性双卵双胞胎），有出生体重信息，以及在1至69岁期间共112,409对身高测量值。19,881对完整双胞胎有出生身长信息，以及共72,692对身高测量值。通过线性回归分析在个体和双胞胎对内水平分析出生体型与后期身高之间的关联。
在双胞胎对内，回归系数显示出生体重增加1千克和出生身长增加1厘米分别与身高增加1.14 - 4.25厘米和0.18 - 0.90厘米相关。双卵双胞胎对内的关联程度通常大于单卵双胞胎对内，且这种合子类型之间的差异在出生身长方面更为明显。
遗传和个体特异性环境因素在出生体型与从婴儿期到成年期后期身高的关联中均起作用，其中遗传因素在与出生身长的关联中比与出生体重的关联中作用更大。
