Hovatta O, Lähteenmäki A, Lemola R, von Smitten K
Infertility Clinic of the Finnish Population and Family Welfare Federation, Helsinki.
Hum Reprod. 1993 Oct;8(10):1692-5. doi: 10.1093/oxfordjournals.humrep.a137915.
Infertility due to obstructive azoospermia in 24 men was treated with a combination of scrotal exploration, microsurgical sperm aspiration and vasoepididymostomy, at the same operation. In-vitro fertilization (IVF) and embryo transfer were performed using epididymal spermatozoa. Donor spermatozoa were used if no motile epididymal spermatozoa were obtained. With this combination, emotionally and economically acceptable pregnancy rates were achieved: 24% per aspiration, 43% per embryo transfer, and 25% per couple. One twin pregnancy resulting in the birth of two healthy female infants and one ongoing twin pregnancy were achieved with epididymal spermatozoa; four pregnancies (one twin, two singletons, one abortion) were achieved with donor spermatozoa.
24名因梗阻性无精子症导致不育的男性在同一次手术中接受了阴囊探查、显微外科精子抽吸和输精管附睾吻合术联合治疗。使用附睾精子进行体外受精（IVF）和胚胎移植。如果未获得活动的附睾精子，则使用供体精子。通过这种联合治疗，获得了在情感和经济上都可接受的妊娠率：每次抽吸为24%，每次胚胎移植为43%，每对夫妇为25%。使用附睾精子实现了一次双胞胎妊娠并产下两名健康女婴，还有一次双胞胎妊娠仍在进行；使用供体精子实现了四次妊娠（一次双胞胎、两次单胎、一次流产）。
