Akopov S E, Gabrielian E S
Department of Pharmacology, Yerevan Medical Institute, Armenia.
J Clin Pharmacol. 1993 Nov;33(11):1048-51. doi: 10.1002/j.1552-4604.1993.tb01941.x.
Blood and plasma from 109 patients with atherosclerosis and 70 healthy volunteers were tested to study the rate of prostacyclin (PGI2) hydrolysis. It has been reported that patients with atherosclerosis have the enhanced velocity of PGI2 degradation. The increase in the velocity was more marked in blood than in plasma. The significant negative correlation between antiaggregation effects of pentoxifylline, nifedipine, and dipyridamole and the velocity of PGI2 degradation in the patients was found. These data suggest that the increase of PGI2 biosynthesis by the drugs studied can enhance their antiaggregation effect if processes of PGI2 degradation in blood are not accelerated.
对109例动脉粥样硬化患者和70名健康志愿者的血液及血浆进行检测，以研究前列环素（PGI2）的水解速率。据报道，动脉粥样硬化患者PGI2降解速度加快。血液中PGI2降解速度的增加比血浆中更明显。在患者中发现己酮可可碱、硝苯地平和双嘧达莫的抗聚集作用与PGI2降解速度之间存在显著负相关。这些数据表明，如果血液中PGI2的降解过程不加速，所研究药物增加PGI2的生物合成可增强其抗聚集作用。
