Effects of drugs acting on platelet and neutrophil aggregation depending on their interaction.

In vitro it was confirmed that direct interactions between platelets and neutrophils enhanced the process of the formation of cell aggregates. The interaction decreased the ability of prostacyclin, aspirin, propranolol and nifedipine to reduce platelet and neutrophil aggregation. This decrease was more marked for aspirin and prostacyclin but antiaggregation effects of propranolol and nifedipine were more stable to the influence of platelet-neutrophil interaction. It was assumed that the cell interactions might cause the decrease in the efficiency of antiaggregant therapy in patients with cardiovascular disorders.