Akopov S, Grigorian M, Gabrielian E
Department of Pharmacology, Yerevan Medical Institute, Armenia, USSR.
Methods Find Exp Clin Pharmacol. 1991 Nov;13(9):591-4.
In vitro it was confirmed that direct interactions between platelets and neutrophils enhanced the process of the formation of cell aggregates. The interaction decreased the ability of prostacyclin, aspirin, propranolol and nifedipine to reduce platelet and neutrophil aggregation. This decrease was more marked for aspirin and prostacyclin but antiaggregation effects of propranolol and nifedipine were more stable to the influence of platelet-neutrophil interaction. It was assumed that the cell interactions might cause the decrease in the efficiency of antiaggregant therapy in patients with cardiovascular disorders.
在体外实验中已证实，血小板与中性粒细胞之间的直接相互作用会增强细胞聚集体的形成过程。这种相互作用降低了前列环素、阿司匹林、普萘洛尔和硝苯地平减少血小板和中性粒细胞聚集的能力。阿司匹林和前列环素的这种降低更为明显，但普萘洛尔和硝苯地平的抗聚集作用对血小板 - 中性粒细胞相互作用的影响更稳定。据推测，细胞间相互作用可能会导致心血管疾病患者抗聚集治疗的效率降低。
