亚甲蓝及其类似物与DNA和其他生物底物的光化学相互作用。
Photochemical interactions of methylene blue and analogues with DNA and other biological substrates.
作者信息
Tuite E M, Kelly J M
机构信息
Chemistry Department, Trinity College, Dublin, Ireland.
出版信息
J Photochem Photobiol B. 1993 Dec;21(2-3):103-24. doi: 10.1016/1011-1344(93)80173-7.
PMID:8301408
Abstract
The light-induced reactions of methylene blue and related phenothiazinium dyes with biological substrates are described. The properties of the excited states of the dyes, their reactions with nucleic acids and their photosensitised chemical modifications of nucleic acid bases are examined. Reports on phenothiazinium dye-induced damage to proteins, lipids, biological membranes, organelles, viruses, bacteria, mammalian cells and carcinomas are reviewed.
摘要
本文描述了亚甲蓝及相关吩噻嗪鎓染料与生物底物的光诱导反应。研究了染料激发态的性质、它们与核酸的反应以及它们对核酸碱基的光敏化学修饰。综述了关于吩噻嗪鎓染料对蛋白质、脂质、生物膜、细胞器、病毒、细菌、哺乳动物细胞和癌的损伤的报道。
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