镰状细胞性状婴儿患婴儿猝死综合征的发病率。

Incidence of sudden infant death syndrome in infants with sickle cell trait.

作者信息

Gozal D, Lorey F W, Chandler D, Derry M K, Lisbin A, Keens T G, Cunningham G C, Ward S L

机构信息

Division of Neonatology and Pediatric Pulmonology, Childrens Hospital Los Angeles, CA 90027.

出版信息

J Pediatr. 1994 Feb;124(2):211-4. doi: 10.1016/s0022-3476(94)70305-1.

DOI:10.1016/s0022-3476(94)70305-1

PMID:8301424

Abstract

The significantly higher incidence of both sickle cell trait (SCT) and sudden infant death syndrome (SIDS) in the black population suggests that SCT and SIDS may be epidemiologically related. To study this possibility, we identified, for the period of February 1990 to February 1992, all infants with SCT born in Los Angeles County whose disease was diagnosed through the California Newborn Screening Program. We matched these infants with all confirmed cases of SIDS in Los Angeles County from February 1990 to March 1993. Three cases of SCT among 589 infants confirmed to have had SIDS were identified. The incidence of SIDS was 1.25/1000 live births for the general population versus 0.58/1000 cases for the SCT group. This finding remained unchanged when rates were adjusted for ethnicity. We conclude that infants born with SCT are not at increased risk of dying of SIDS.

摘要

黑人人群中镰状细胞性状（SCT）和婴儿猝死综合征（SIDS）的发病率显著更高，这表明SCT和SIDS在流行病学上可能存在关联。为了研究这种可能性，我们确定了1990年2月至1992年2月期间在洛杉矶县出生且通过加利福尼亚新生儿筛查计划确诊患有SCT的所有婴儿。我们将这些婴儿与1990年2月至1993年3月期间洛杉矶县所有确诊的SIDS病例进行匹配。在589例确诊患有SIDS的婴儿中，发现了3例SCT病例。一般人群中SIDS的发病率为1.25/1000活产，而SCT组为0.58/1000例。在对种族进行调整后，这一发现保持不变。我们得出结论，患有SCT的婴儿死于SIDS的风险并未增加。