John E G, Fornell L C, Radhakrishnan J, Anutrakulchai S, Jonasson O
Division of Pediatric Nephrology, University of Illinois, Chicago.
J Pediatr Surg. 1993 Nov;28(11):1429-31; discussion 1432. doi: 10.1016/0022-3468(93)90425-k.
Cyclosporin A has markedly improved graft survival in transplant patients but its side effects, such as renal toxicity and hypertension, pose management problems in transplant recipients. This toxicity has been attributed to prostaglandin inhibition. Concurrent administration of misoprostol (a prostaglandin E1 analog) prevents chronic cyclosporin A-induced nephrotoxicity but not hypertension in rats.
环孢素A显著提高了移植患者的移植物存活率，但其副作用，如肾毒性和高血压，给移植受者带来了管理难题。这种毒性被认为与前列腺素抑制有关。在大鼠中，同时给予米索前列醇（一种前列腺素E1类似物）可预防环孢素A诱导的慢性肾毒性，但不能预防高血压。
