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腘动脉瘤:当前的治疗与预后

Popliteal artery aneurysms: current management and outcome.

作者信息

Carpenter J P, Barker C F, Roberts B, Berkowitz H D, Lusk E J, Perloff L J

机构信息

Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia.

出版信息

J Vasc Surg. 1994 Jan;19(1):65-72; discussion 72-3. doi: 10.1016/s0741-5214(94)70121-0.

Abstract

PURPOSE

Thrombosis of popliteal artery aneurysms can produce limb-threatening ischemia. In this setting we have found preoperative thrombolytic therapy to be beneficial.

METHODS

Thirty-three patients with 54 popliteal artery aneurysms were studied (mean follow-up 62 months). Twenty-one patients (62%) had bilateral popliteal artery aneurysms, and 20 patients (61%) had extrapopliteal arterial aneurysms. Thirty-three (61%) aneurysms had symptoms of compression or ischemia, and 21 (39%) aneurysms had thrombosis. A trend toward thrombosis for larger aneurysms was noted (p < 0.068).

RESULTS

Forty-five aneurysms were treated with bypass grafting. Five-year graft patency and limb salvage rates were 71% and 90%, respectively. Factors favoring graft patency and limb salvage included presence of two- or three-vessel runoff compared with patients with single- or no-vessel runoff (p < 0.025 graft patency; p < 0.003 limb salvage) and presence of a patent aneurysm (p < 0.005 graft patency and limb salvage). Seven patients diagnosed with thrombosis of their aneurysm and all runoff vessels were treated with preoperative thrombolytic therapy. Complete clearing of thrombus from these arteries was achieved in six of these patients (and from two of these runoff vessels in the remaining patient). These patients had better graft patency (p < 0.005) and limb salvage (p < 0.01) than comparable patients treated with emergency operations. Six amputations were performed in the follow-up interval, none of which were performed in patients having undergone thrombolytic therapy.

CONCLUSIONS

It is concluded that popliteal aneurysms are managed best by elective repair of patent aneurysms with good runoff. In that difficult situation of the thrombosed popliteal artery aneurysm associated with acute leg ischemia, thrombolytic therapy safely and effectively provides patients with a more favorable alternative than emergency surgery.

摘要

目的

腘动脉瘤血栓形成可导致肢体缺血,威胁肢体安全。在此情况下,我们发现术前溶栓治疗有益。

方法

对33例患有54个腘动脉瘤的患者进行了研究(平均随访62个月)。21例患者(62%)患有双侧腘动脉瘤,20例患者(61%)患有腘外动脉动脉瘤。33个(61%)动脉瘤有压迫或缺血症状,21个(39%)动脉瘤有血栓形成。观察到较大动脉瘤有血栓形成的趋势(p<0.068)。

结果

45个动脉瘤接受了旁路移植术治疗。5年移植通畅率和肢体挽救率分别为71%和90%。有利于移植通畅和肢体挽救的因素包括与单支或无血管分支的患者相比,存在双支或三支血管分支(移植通畅率p<0.025;肢体挽救率p<0.003)以及存在未闭动脉瘤(移植通畅率和肢体挽救率p<0.005)。7例诊断为动脉瘤及其所有分支血管血栓形成的患者接受了术前溶栓治疗。其中6例患者这些动脉的血栓完全清除(其余1例患者的2个分支血管血栓清除)。这些患者的移植通畅率(p<0.005)和肢体挽救率(p<0.01)优于接受急诊手术的类似患者。随访期间进行了6次截肢手术,接受溶栓治疗的患者均未进行截肢。

结论

结论是,腘动脉瘤最好通过择期修复未闭且有良好血管分支的动脉瘤来处理。在伴有急性下肢缺血的血栓形成的腘动脉瘤这种困难情况下,溶栓治疗比急诊手术能安全有效地为患者提供更有利的选择。

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