Matsuki A, Ishihara H, Sakai T, Kotani N, Hashimoto H, Asai M, Hirota K, Koh H, Wakayama S, Satoh Y
Department of Anesthesiology, University of Hirosaki School of Medicine.
Masui. 1993 Dec;42(12):1738-43.
Total intravenous anesthesia with droperidol, fentanyl and ketamine (DFK) was given to over three thousand patients during four years from April 1989 through March 1993. The patients ranged in age from three months to eighty seven years. They underwent surgical, orthopedic, gynecological, thoracic, plastic and otolaryngeal surgeries, but patients who underwent craniotomy and obstetric operations were excluded. None of them developed any serious complications primarily due to DFK. DFK has many advantages such as the broad safety margin for three agents employed in DFK, no accident by N2O, no air pollution, empty bowels, no increase in middle ear pressure etc, while this has disadvantages such as high blood pressure, slow awakening from anesthesia and unpleasant dreams. Calcium channel blockers are very effective for antagonizing high blood pressure, and rapid recovery from anesthesia can be easily obtained by reducing ketamine dose given and also by application of epidural block. Intraoperative dreams may be avoided by concomitant use of benzodiazepines. Thus we are convinced that DFK can be a good as well as convenient anesthetic method for clinical anesthesia.
1989年4月至1993年3月的四年间，超过三千名患者接受了氟哌利多、芬太尼和氯胺酮全静脉麻醉（DFK）。患者年龄从三个月到八十七岁不等。他们接受了外科、骨科、妇科、胸科、整形和耳鼻喉科手术，但接受开颅手术和产科手术的患者被排除在外。他们中没有一人主要因DFK出现任何严重并发症。DFK有许多优点，如DFK中使用的三种药物安全范围广、无N₂O意外、无污染空气、肠道空虚、中耳压力无增加等，而其缺点有高血压、麻醉苏醒缓慢和梦境不愉快。钙通道阻滞剂对拮抗高血压非常有效，通过减少氯胺酮用量以及应用硬膜外阻滞可轻松实现麻醉快速苏醒。术中使用苯二氮䓬类药物可避免做梦。因此，我们确信DFK可以成为一种良好且方便的临床麻醉方法。
