Yang W H
Department of Mechanical Engineering and Applied Mechanics, University of Michigan, Ann Arbor 48109-2125.
J Biomech Eng. 1993 Nov;115(4B):617-21. doi: 10.1115/1.2895549.
Thermal (or heat) shock phenomena have been observed in all organisms at the cellular level. They cause an acceleration in the rate of expression of specific genes (heat shock genes), resulting in an increase and accumulation of heat shock proteins in cells. The purpose of this study is to investigate the mechanisms of thermal shock from two different viewpoints: biothermal and biothermomechanical aspects. The former predicts more severe consequences on cells that the latter, whose thermal wave fronts are smoothed due to the coupling effects of thermoelasticity. In conclusion, it is the thermal wave propagation (the so-called "second sound" effect) which triggers a perturbation of normal gene expression. Thermotolerance is found to be inherited in the heat flux equation of the thermal wave model. The information obtained from this study can also be useful to therapeutical hyperthermia, preservation of organs and tissues, and laser and cryogenic surgery.
在细胞水平上，所有生物体中均观察到热（或热激）休克现象。它们会导致特定基因（热休克基因）的表达速率加快，从而使热休克蛋白在细胞中增加并积累。本研究的目的是从两个不同的角度研究热休克机制：生物热学和生物热机械学方面。前者预测对细胞的影响比后者更严重，后者的热波前沿由于热弹性耦合效应而变得平滑。总之，是热波传播（所谓的“第二声”效应）引发了正常基因表达的扰动。在热波模型的热通量方程中发现热耐受性是可遗传的。从这项研究中获得的信息对于治疗性热疗、器官和组织的保存以及激光和冷冻手术也可能有用。
