大鼠脑中GABAA受体γ1和γ2亚基的差异免疫细胞化学定位
Differential immunocytochemical localization of GABAA receptor gamma 1 and gamma 2 subunits in the rat brain.
作者信息
Araki T, Kiyama H, Maeno H, Tohyama M
机构信息
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan.
出版信息
Brain Res Mol Brain Res. 1993 Nov;20(3):263-6. doi: 10.1016/0169-328x(93)90050-y.
Subunit-specific polyclonal antisera against the GABAA receptor gamma 1 and gamma 2 subunits were raised in rabbits and used for immunoblotting and immunocytochemistry of the rat brain. Each subunit protein was differentially distributed even in the region like cerebellar cortex where mRNAs of both subunits were distributed in the same manner. This may indicate that GABAA receptor gamma 1 and gamma 2 subunit proteins are subject to a subunit-specific subcellular sorting mechanism.
针对GABAA受体γ1和γ2亚基的亚基特异性多克隆抗血清在兔体内产生，并用于大鼠脑的免疫印迹和免疫细胞化学研究。即使在小脑皮质这样两个亚基的mRNA以相同方式分布的区域，每个亚基蛋白的分布也存在差异。这可能表明GABAA受体γ1和γ2亚基蛋白受到亚基特异性的亚细胞分选机制的作用。
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