Jomary C, Murphy B F, Neal M J, Jones S E
Department of Pharmacology, Rayne Institute, St Thomas' Hospital, London, UK.
Brain Res Mol Brain Res. 1993 Nov;20(3):274-8. doi: 10.1016/0169-328x(93)90052-q.
Increased expression of clusterin mRNA is associated with neurodegenerative states, including retinas affected by retinitis pigmentosa (RP). We have investigated the distribution of immunoreactive clusterin in normal and RP-affected retinas. Reactivity at the inner limiting membrane, plexiform layers, and photoreceptors in normal retina accords well with clusterin's postulated role as a membrane protective agent. In RP-affected retina the organized distribution is lost and overall reactivity appears decreased. The changes in this case may reflect increased turnover or removal of clusterin, perhaps via interaction with components of the immune system.
簇集素mRNA表达增加与神经退行性状态相关，包括受色素性视网膜炎（RP）影响的视网膜。我们研究了免疫反应性簇集素在正常视网膜和受RP影响的视网膜中的分布。正常视网膜内界膜、神经丛层和光感受器的反应性与簇集素作为膜保护剂的假定作用非常吻合。在受RP影响的视网膜中，有组织的分布消失，总体反应性似乎降低。这种情况下的变化可能反映了簇集素更新或清除的增加，可能是通过与免疫系统成分的相互作用。
