Lightwood R, Reber H A
Gastroenterology. 1977 Jan;72(1):61-6.
Using micropuncture techniques, pancreatic electrolyte secretion was studied in 50 female mongrel cats. During maximal secretin stimulation (GIH, 4 to 6 U per kg-hr), juice was collected from intralobular (10 to 50 mu diameter), and extralobular (25 to 300 mu diameter) ducts by micropuncture and compared with juice simultaneously collected from the main duct. The juice [Cl-] steadily decreased from intralobular ducts (112 +/- 9 mEq per liter) to the main duct (46 +/- 8 mEq per liter). During in vivo perfusion, secretion of H2O and HCO3- by the extralobular ducts (25 to 150 mu diameter) was sensitive to secretin. There was no evidence for secretion by the main duct. Pancreatic secretion of water and electrolytes appears to result from the admixture of a Cl-rich primary secretion originating from intralobular structures and a larger volume of HCO3- -rich fluid originating from the smaller extralobular ducts. HCO3- cl- exchange in these ducts accounts for the characteristic changes in concentrations of HCO3- and Cl- as the flow rate varies.
采用微穿刺技术，对50只雌性杂种猫的胰腺电解质分泌情况进行了研究。在最大促胰液素刺激（生长抑素，每千克每小时4至6单位）期间，通过微穿刺从小叶内导管（直径10至50微米）和小叶外导管（直径25至300微米）收集胰液，并与同时从主胰管收集的胰液进行比较。胰液中的[Cl⁻]从小叶内导管（每升112±9毫当量）稳步下降至主胰管（每升46±8毫当量）。在体内灌注期间，小叶外导管（直径25至150微米）对促胰液素刺激的水和HCO₃⁻分泌敏感。未发现主胰管有分泌迹象。胰腺水和电解质的分泌似乎是由源自小叶内结构的富含Cl⁻的初级分泌液与源自较小的小叶外导管的大量富含HCO₃⁻的液体混合而成。随着流速变化，这些导管中的HCO₃⁻-Cl⁻交换导致了HCO₃⁻和Cl⁻浓度的特征性变化。
