De Cesaris R, Ranieri G, Bonfantino V, Adriani A, Filitti V, Ferrieri A
Cattedra di Terapia Medica, Università degli Studi di Bari.
Minerva Cardioangiol. 1993 Oct;41(10):457-63.
The anti-hypertensive activity and influence on some forms of stress of slow-release Nicardipoine and Captopril were compared using a randomized 2:1 protocol. Thirty-six patients, mean age 55.9 years, suffering from slight or moderate arterial hypertension were treated with either 40 mg of Nicardipine retard twice a day (b.i.d.), or Captopril in a dose of 25 mg (b.i.d.) for 8 weeks. A significant reduction was observed in arterial pressure, both in orthostatism and clinostatism, following both treatments in comparison to the placebo period, but the group treated with slow-release Nicardipine showed a greater and statistically significant reduction in arterial pressure. No significant change in heart rate was reported using either drug. Non-invasive out-patient monitoring of arterial pressure, performed using Spacelabs 5300, showed a significant reduction in arterial pressure using both drugs and the conservation of the normal circadian rhythm of arterial pressure. The pressure response to the cold pressor test (CPT), mental arithmetic test (MAS), and to dynamic and isometric effort was positive with both drugs, thus revealing a degree of protection offered by treatment using these two substances. In overall terms, the two drugs were well tolerated.
采用随机2:1方案比较了缓释尼卡地平与卡托普利的抗高血压活性以及对某些形式应激的影响。36例平均年龄55.9岁的轻度或中度动脉高血压患者，分别接受每日两次40mg缓释尼卡地平或每日两次25mg卡托普利治疗，为期8周。与安慰剂期相比，两种治疗后无论是立位还是卧位，动脉压均显著降低，但缓释尼卡地平治疗组动脉压降低幅度更大且具有统计学意义。两种药物均未报告心率有显著变化。使用太空实验室5300进行的非侵入性门诊动脉压监测显示，两种药物均使动脉压显著降低，且保留了正常的动脉压昼夜节律。两种药物对冷加压试验（CPT）、心算试验（MAS）以及动态和等长运动的压力反应均为阳性，从而揭示了使用这两种药物治疗所提供的一定程度的保护作用。总体而言，两种药物耐受性良好。
