De Cesaris R, Ranieri G, Andriani A, Filitti V, Bonfantino M V, Lamontanara G, Ferrieri A
Dipartimento di Scienze Biomediche, Università degli Studi, Policlinico, Bari.
Minerva Med. 1993 Oct;84(10):533-9.
Thirty-six patients (17 males and 19 females), aged between 40 and 70 years old (mean age 55.9), suffering from slight or moderate arterial hypertension, were monitored for four weeks after 14 days of placebo treatment. In a double-blind and random study 24 patients were treated with Nicardipine Retard (40 mg twice a day) whereas a further 12 received placebo twice a day. Sphigomanometric controls carried out after two and four weeks showed a significant reduction in arterial pressure only in those patients receiving active treatment. 24-hour out-patient monitoring of arterial pressure, carried out using Spacelabs 5300, showed a reduction in both systolic and diastolic arterial pressure throughout the day in subjects treated with calcium-antagonists compared to the placebo group. The normal physiological 24-hour trend of arterial pressure was always taken into account. The pressure response to a cold pressor test, mental arithmetic test, isometric and dynamic effort tests, measuring using a cycloergometer, was not modified by anti-hypertensive treatment, thus confirming the preservation of normal physiological behaviour during daily activities. There was no significant change in heart rate and the drug was well tolerated.
36例年龄在40至70岁之间（平均年龄55.9岁）、患有轻度或中度动脉高血压的患者（17名男性和19名女性），在接受14天安慰剂治疗后被监测四周。在一项双盲随机研究中，24例患者接受缓释尼卡地平治疗（每日两次，每次40毫克），另外12例患者每日两次接受安慰剂治疗。在两周和四周后进行的血压测量对照显示，只有接受积极治疗的患者动脉压有显著降低。使用太空实验室5300对动脉压进行24小时门诊监测，结果显示，与安慰剂组相比，接受钙拮抗剂治疗的受试者全天收缩压和舒张压均有所降低。始终考虑到动脉压正常的24小时生理趋势。使用自行车测力计测量的对冷加压试验、心算试验、等长和动态用力试验的压力反应，并未因抗高血压治疗而改变，从而证实了日常活动期间正常生理行为得以保留。心率无显著变化，且该药物耐受性良好。
