p53基因第36密码子处的多态性。
Polymorphism at codon 36 of the p53 gene.
作者信息
Felix C A, Brown D L, Mitsudomi T, Ikagaki N, Wong A, Wasserman R, Womer R B, Biegel J A
机构信息
Department of Pediatrics, Children's Hospital of Philadelphia, Pennsylvania 19104.
出版信息
Oncogene. 1994 Jan;9(1):327-8.
A polymorphism at codon 36 in exon 4 of the p53 gene was identified by single strand conformation polymorphism (SSCP) analysis and direct sequencing of genomic DNA PCR products. The polymorphic allele, present in the heterozygous state in genomic DNAs of four of 100 individuals (4%), changes the codon 36 CCG to CCA, eliminates a FinI restriction site and creates a BccI site. Including this polymorphism there are four known polymorphisms in the p53 coding sequence.
通过单链构象多态性（SSCP）分析和基因组DNA PCR产物的直接测序，在p53基因第4外显子的36密码子处鉴定出一种多态性。这种多态性等位基因在100个个体中的4个个体（4%）的基因组DNA中以杂合状态存在，它将36密码子CCG变为CCA，消除了一个FinI限制性酶切位点并产生了一个BccI位点。包括这种多态性在内，p53编码序列中有四种已知的多态性。
Zotero 插件