恒河猴的主要组织相容性复合体。VI. Ia类抗原的血清学与遗传学

The major histocompatibility complex of rhesus monkeys. VI. Serology and genetics of Ia-like antigens.

作者信息

Roger J H, van Vreeswijk W, Dorf M E, Balner H

出版信息

Tissue Antigens. 1976 Jul;8(1):67-86. doi: 10.1111/j.1399-0039.1976.tb00554.x.

DOI:10.1111/j.1399-0039.1976.tb00554.x

Abstract

The serology and genetics of11 new cell surface alloantigens of rhesus monkeys are described: They are controlled by the mamor histocompatibility complex but are distinct from the conventional serologically defined (SD) antigens ofRhL-A. The new specifications are termed "Ia-like" because ofserological, immunocytological and other characteristics reminiscent of Ia-antigens of the mouse. Population and family analyses led to the postulation of two segregant series controlling eight of the 11 Ia-like specificities of the monkey. Strong linkage disequilibria with SD2 antigens and genetic mapping on the basis of segregation studies in recombinant offspring in the monkey families, places at least one of the two loci in the vicinity of the SD2 locus of RhL-A, not in the region of the major MLC or LD1 locus. For this and other reasons, the new B-cell alloantigens of rhesus monkeys are not believed to be similar to or associated with the stimulator antigens of LD1. The biological function(s) of the Ia-like antigens of primates are as yet unknown.

摘要

本文描述了恒河猴11种新的细胞表面同种异体抗原的血清学和遗传学特征：它们受主要组织相容性复合体控制，但与恒河猴白细胞抗原（RhL-A）传统血清学定义（SD）抗原不同。由于血清学、免疫细胞学及其他特征使人联想到小鼠的Ia抗原，这些新的特异性抗原被称为“Ia样”抗原。群体和家系分析结果表明，存在两个分离系列控制着恒河猴11种Ia样特异性中的8种。在猴家族的重组后代中，基于分离研究的SD2抗原强连锁不平衡和基因定位表明，这两个基因座中至少有一个位于RhL-A的SD2基因座附近，而非主要混合淋巴细胞培养（MLC）或LD1基因座区域。基于上述及其他原因，恒河猴新的B细胞同种异体抗原被认为与LD1的刺激抗原不相似或无关联。灵长类动物Ia样抗原的生物学功能尚不清楚。