细胞周期蛋白依赖性激酶6（PLSTIRE）和细胞周期蛋白依赖性激酶4（PSK-J3）是与细胞周期蛋白D1相关的细胞周期蛋白依赖性激酶中的一个独特亚群。

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

作者信息

Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C, Peters G

机构信息

Imperial Cancer Research Fund Laboratories, London, UK.

出版信息

Oncogene. 1994 Jan;9(1):71-9.

PMID:8302605

Abstract

Deregulated expression of cyclin D1 is a feature of several neoplastic and proliferative disorders, but its normal role in the cell cycle remains unclear. Here we show that in a squamous carcinoma cell line with 11-fold amplification of the CCND1 gene, cyclin D1 associates specifically with p33cdk4 (PSK-J3) and p38cdk6 (PLSTIRE), two closely related members of the cyclin-dependent kinase (CDK) family. In these tumour cells, there is little evidence for an association between cyclin D1 and other CDKs, but in diploid human fibroblasts both CDK2 and CDK5 can be co-precipitated with cyclin D1, as well as CDK4. The data suggest that D-type cyclins participate in multiple interactions with CDKs but that the nature or stoichiometry of these associations may differ in different types of cell.

摘要

细胞周期蛋白D1的表达失调是几种肿瘤性和增殖性疾病的一个特征，但其在细胞周期中的正常作用仍不清楚。在这里，我们表明，在一个CCND1基因有11倍扩增的鳞状癌细胞系中，细胞周期蛋白D1特异性地与细胞周期蛋白依赖性激酶（CDK）家族的两个密切相关成员p33cdk4（PSK-J3）和p38cdk6（PLSTIRE）结合。在这些肿瘤细胞中，几乎没有证据表明细胞周期蛋白D1与其他CDK之间存在关联，但在二倍体人成纤维细胞中，CDK2和CDK5以及CDK4都可以与细胞周期蛋白D1共沉淀。数据表明，D型细胞周期蛋白参与了与CDK的多种相互作用，但这些关联的性质或化学计量在不同类型的细胞中可能有所不同。