Remmele W, Schicketanz K H
Institut für Pathologie, Kliniken der Landeshauptstadt Wiesbaden, FRG.
Pathol Res Pract. 1993 Sep;189(8):862-6. doi: 10.1016/S0344-0338(11)81095-2.
Immunohistochemistry of Estrogen Receptor (ER) and Progesterone Receptor (PR) has been performed in 687 cases of human breast cancer. The staining results have been compared by (1) computer-assisted image analysis (QIC Score) and (2) subjective grading of the cryostat sections ("German" IRS). Tumors without or with only weak ER or PR content may be distinguished by both methods from tumors with a high receptor content. The QIC Score values belonging to the intermediate IRS grades are distributed over a wide range, but no negative cases were found in these categories. It is concluded from our results that subjective grading of the slides is a simple, rapid and useful method for the determination of the tissue receptor content and must not be replaced by the expensive and time-consuming computer-assisted image analysis in daily practice.
对687例人类乳腺癌病例进行了雌激素受体（ER）和孕激素受体（PR）的免疫组织化学检测。通过（1）计算机辅助图像分析（QIC评分）和（2）低温恒温器切片的主观分级（“德国”IRS）对染色结果进行了比较。两种方法均可区分ER或PR含量无或仅为弱阳性的肿瘤与受体含量高的肿瘤。属于中等IRS分级的QIC评分值分布范围很广，但在这些类别中未发现阴性病例。我们的结果表明，对切片进行主观分级是一种简单、快速且有用的确定组织受体含量的方法，在日常实践中绝不能被昂贵且耗时的计算机辅助图像分析所取代。
