肺栓塞与心脏病。一项尸检研究。

Pulmonary embolism and heart disease. An autopsy study.

作者信息

Karwinski B, Svendsen E, Seim S

机构信息

Department of Pathology, Gade Institute, University of Bergen, Norway.

出版信息

Pathol Res Pract. 1993 Nov;189(9):1058-62. doi: 10.1016/S0344-0338(11)80680-1.

DOI:10.1016/S0344-0338(11)80680-1

PMID:8302725

Abstract

The frequency of pulmonary embolism in patients with myocardial infarction (MI) and chronic rheumatic heart disease (RHE) has been investigated in an autopsy series. The series comprised 21530 hospital autopsies from 1960 to 1984. Altogether 5351 patients with MI and 289 patients with RHE as underlying death cause were selected for this study. Patients with RHE or old myocardial infarction (OMI) had a significantly higher frequency of pulmonary embolism than patients with acute myocardial infarction (AMI) or acute and old myocardial infarction combined (AOMI). This was true irrespective of duration of stay in the hospital during last admission. The frequency of pulmonary embolism decreased in patients with OMI or RHE from 1960 to 1984 suggestive of better therapy of chronic heart failure. A similar trend was seen in patients with AMI during a period with consistent anticoagulation treatment.

摘要

在一个尸检系列中，对心肌梗死（MI）和慢性风湿性心脏病（RHE）患者肺栓塞的发生率进行了调查。该系列包括1960年至1984年期间的21530例医院尸检。本研究共选取了5351例以MI为潜在死因的患者和289例以RHE为潜在死因的患者。患有RHE或陈旧性心肌梗死（OMI）的患者肺栓塞发生率明显高于急性心肌梗死（AMI）或急性和陈旧性心肌梗死合并（AOMI）的患者。无论上次住院期间的住院时间长短，都是如此。1960年至1984年期间，OMI或RHE患者的肺栓塞发生率有所下降，提示慢性心力衰竭的治疗有所改善。在持续进行抗凝治疗的时期，AMI患者也出现了类似趋势。