In vitro/in vivo models for peptide oral absorption: comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides.

Suppr

超能文献

作者信息

Conradi R A, Wilkinson K F, Rush B D, Hilgers A R, Ruwart M J, Burton P S

机构信息

Drug Delivery Systems Research, Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.

出版信息

Pharm Res. 1993 Dec;10(12):1790-2. doi: 10.1023/a:1018990602102.

DOI:10.1023/a:1018990602102

PMID:8302767

Abstract

摘要

相似文献

In vitro/in vivo models for peptide oral absorption: comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides.

Pharm Res. 1993 Dec;10(12):1790-2. doi: 10.1023/a:1018990602102.

Evaluation of the bile acid transporter in enhancing intestinal permeability to renin-inhibitory peptides.

J Drug Target. 1993;1(4):347-59. doi: 10.3109/10611869308996094.

The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models.

Peptides. 2008 Aug;29(8):1312-20. doi: 10.1016/j.peptides.2008.03.021. Epub 2008 Apr 8.

Effects of structural modifications on the intestinal permeability of angiotensin II receptor antagonists and the correlation of in vitro, in situ, and in vivo absorption.

Pharm Res. 1996 Feb;13(2):227-33. doi: 10.1023/a:1016086930019.

Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway.

Mol Pharm. 2018 Aug 6;15(8):3468-3477. doi: 10.1021/acs.molpharmaceut.8b00466. Epub 2018 Jul 25.

Correlation of in vitro and in vivo models for the oral absorption of peptide drugs.

Amino Acids. 2008 Jun;35(1):233-41. doi: 10.1007/s00726-007-0581-5. Epub 2007 Aug 30.

Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties.

J Med Chem. 1991 Oct;34(10):3140-3. doi: 10.1021/jm00114a026.

Transport of peptidomimetic renin inhibitors across monolayers of a human intestinal cell line (Caco-2): evidence for self-enhancement of paracellular transport route.

Pharm Res. 1995 Nov;12(11):1801-5. doi: 10.1023/a:1016246629130.

Oral absorption of D-oligopeptides in rats via the paracellular route.

Pharm Res. 1996 Nov;13(11):1673-8. doi: 10.1023/a:1016440707092.

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells.

Biochem Biophys Res Commun. 1991 Mar 29;175(3):880-5. doi: 10.1016/0006-291x(91)91647-u.

引用本文的文献

Bioavailability of Rosehip ( L.) Infusion Phenolics Prepared by Thermal, Pulsed Electric Field and High Pressure Processing.

Foods. 2022 Jul 1;11(13):1955. doi: 10.3390/foods11131955.

Modeling kinetics of subcellular disposition of chemicals.

Chem Rev. 2009 May;109(5):1793-899. doi: 10.1021/cr030440j.

Improved prediction of in vivo peroral absorption from in vitro intestinal permeability using an internal standard to control for intra- and inter-rat variability.

Pharm Res. 1997 Dec;14(12):1792-7. doi: 10.1023/a:1012148300807.

Intestinal absorption screening of mixtures from combinatorial libraries in the Caco-2 model.

Pharm Res. 1997 May;14(5):572-7. doi: 10.1023/a:1012140709158.

An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro.

Pharm Res. 1996 Jan;13(1):23-6. doi: 10.1023/a:1016060729594.

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.

Pharm Res. 1995 May;12(5):693-9. doi: 10.1023/a:1016207525186.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验