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An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro.

作者信息

Rubas W, Cromwell M E, Mrsny R J, Ingle G, Elias K A

机构信息

Genentech, Inc., South San Francisco, California 94080-4990, USA.

出版信息

Pharm Res. 1996 Jan;13(1):23-6. doi: 10.1023/a:1016060729594.

DOI:10.1023/a:1016060729594
PMID:8668673
Abstract
摘要

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本文引用的文献

1
Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue.
J Pharm Sci. 1996 Feb;85(2):165-9. doi: 10.1021/js950267+.
2
Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.人结肠上皮（Caco-2）细胞系与兔、猴和犬肠道结肠的通透性特征比较及人体药物吸收情况
Pharm Res. 1993 Jan;10(1):113-8. doi: 10.1023/a:1018937416447.
3
In vitro/in vivo models for peptide oral absorption: comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides.
Pharm Res. 1993 Dec;10(12):1790-2. doi: 10.1023/a:1018990602102.
脂肪酸与上皮通透性：共轭亚油酸对Caco-2细胞的影响。
Gut. 2001 Jun;48(6):797-802. doi: 10.1136/gut.48.6.797.
4
In vitro characterization of four novel classes of growth hormone-releasing peptide.四类新型生长激素释放肽的体外特性研究
Endocrinology. 1995 Dec;136(12):5694-9. doi: 10.1210/endo.136.12.7588325.
5
Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.生长激素促分泌素：特性、功效及最小生物活性构象。
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11165-9. doi: 10.1073/pnas.92.24.11165.
6
Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro.
Endocrinology. 1980 Mar;106(3):663-7. doi: 10.1210/endo-106-3-663.
7
Direct staining and visualization of endothelial monolayers cultured on synthetic polycarbonate filters.在合成聚碳酸酯滤膜上培养的内皮细胞单层的直接染色与可视化。
J Histochem Cytochem. 1988 May;36(5):551-4. doi: 10.1177/36.5.3356897.
8
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.将人结肠癌细胞系（Caco-2）作为肠道上皮通透性模型系统的特性研究
Gastroenterology. 1989 Mar;96(3):736-49.
9
The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.利用培养的上皮细胞和内皮细胞进行药物转运和代谢研究。
Pharm Res. 1990 May;7(5):435-51. doi: 10.1023/a:1015800312910.