Henry J P, Steinberg W M
Department of Medicine, George Washington University Medical Center, Washington, D.C.
Pancreas. 1993 Sep;8(5):622-6. doi: 10.1097/00006676-199309000-00015.
It has recently been shown that the infusion of oleic acid into the rat pancreaticobiliary duct causes a reproducible and long-lasting atrophy of the exocrine pancreas. The effects of this pancreatic atrophy on non-invasive pancreatic function tests have not been fully characterized. This study was undertaken to determine which pancreatic function test was most useful in determining pancreatic insufficiency in this model. Pancreatic insufficiency (PI) was induced in male Wistar rats by oleic acid infusion and three pancreatic function tests were compared in these animals and saline controls. The coefficient of fat absorption on a 5 or 45% fat diet and bentiromide testing could not differentiate animals with or without PI, but fecal chymotrypsin levels were excellent discriminators. All animals with PI had fecal chymotrypsin levels below 67 U/g feces whereas all saline controls were above this level. We conclude that, in this model of PI, the fecal chymotrypsin concentration is the best non-invasive test to determine pancreatic insufficiency.
最近的研究表明，向大鼠胰胆管内注入油酸会导致外分泌胰腺出现可重复且持久的萎缩。这种胰腺萎缩对非侵入性胰腺功能测试的影响尚未完全明确。本研究旨在确定哪种胰腺功能测试在该模型中最有助于判定胰腺功能不全。通过向雄性Wistar大鼠注入油酸诱导胰腺功能不全（PI），并在这些动物和生理盐水对照组中比较三种胰腺功能测试。5%或45%脂肪饮食下的脂肪吸收系数以及苯替酪胺测试无法区分有无PI的动物，但粪便糜蛋白酶水平是很好的判别指标。所有患有PI的动物粪便糜蛋白酶水平均低于67 U/g粪便，而所有生理盐水对照组均高于此水平。我们得出结论，在这个PI模型中，粪便糜蛋白酶浓度是判定胰腺功能不全的最佳非侵入性测试。
