Lai F M, Li P K, Pang S W, Suen M W, Lui S F, To K F, Lai K N
Department of Anatomical and Cellular Pathology and Medicine, Chinese University of Hong Kong, Shatin.
Mod Pathol. 1993 Nov;6(6):684-90.
Eleven diabetic patients with biopsy-proven IgA nephropathy were studied. Seven exhibited coexistence of both IgA nephropathy and diabetic glomerulosclerosis and the remaining four patients had IgA nephropathy without diabetic lesion. The clinicopathological features and follow-up of those patients with IgA nephropathy surperimposed on diabetic glomerulosclerosis were compared with a similar group of patients with diabetic glomerulosclerosis alone. Our observation suggests that the occurrence of both glomerulopathies was fortuitous with IgA nephropathy coexisting with or preceding diabetic glomerulosclerosis. There was no apparent causal relationship between the two glomerulopathies. The renal outcome is poor in both groups of patients and is possibly related to diabetic glomerulosclerosis.
对11例经活检证实为IgA肾病的糖尿病患者进行了研究。其中7例同时存在IgA肾病和糖尿病肾小球硬化，其余4例仅有IgA肾病而无糖尿病病变。将这些叠加在糖尿病肾小球硬化上的IgA肾病患者的临床病理特征及随访情况与一组单纯糖尿病肾小球硬化患者进行了比较。我们的观察表明，两种肾小球病的发生是偶然的，IgA肾病与糖尿病肾小球硬化并存或先于糖尿病肾小球硬化出现。两种肾小球病之间没有明显的因果关系。两组患者的肾脏预后都很差，可能与糖尿病肾小球硬化有关。
