芒草穗水提取物对小鼠IgE形成的抑制作用。
Inhibitory effect of the water extract of spikes of Miscanthus sinensis on IgE formation in mice.
作者信息
Xu H X, Kadota S, Hattori M, Takahashi T, Kojima Y, Namba T
机构信息
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
出版信息
Planta Med. 1993 Dec;59(6):529-32. doi: 10.1055/s-2006-959754.
The effects of four different plant extracts of the spikes of Miscanthus sinensis, Phragmites communis, and Imperata cylindrica var. major, and of the spikelets of Coix lachryma-jobi on IgE antibody formation were investigated in mice. The IgE antibody titer was tested by the passive cutaneous anaphylaxis (PCA) method in rats. Of these, the water extract of M. sinensis showed an appreciable inhibitory effect on IgE formation. Furthermore, an undialyzable fraction of the water extract with a relative molecular mass of more than 50,000 d, designated as MSIS, showed the most potent inhibitory activity on IgE formation. MSIS was also a potent inhibitor of IgE formation when given intraperitoneally or intranasally to mice the day before injection of dinitrophenyl (DNP)-ovalbumin (OVA) antigen in both the primary and secondary immune responses. Moreover, MSIS clearly suppressed on-going IgE antibody formation in both primary and secondary immune responses.
研究了芒草、芦苇、白茅的四种不同植物提取物以及薏苡仁的小穗对小鼠IgE抗体形成的影响。采用被动皮肤过敏反应（PCA）法检测大鼠的IgE抗体滴度。其中，芒草的水提取物对IgE形成有明显的抑制作用。此外，水提取物中相对分子质量大于50,000 d的不可透析部分，命名为MSIS，对IgE形成显示出最强的抑制活性。在初次和二次免疫反应中，在注射二硝基苯基（DNP）-卵清蛋白（OVA）抗原前一天，将MSIS腹腔内或鼻内给予小鼠时，它也是IgE形成的有效抑制剂。此外，MSIS在初次和二次免疫反应中均明显抑制正在进行的IgE抗体形成。
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