Savolainen H
Institute of Occupational Health Sciences, Lausanne, Switzerland.
Res Commun Chem Pathol Pharmacol. 1993 Nov;82(2):241-4.
The excretion of urinary glycosaminoglycans by five occupationally exposed men with urinary cadmium levels of 1 to 6.5 micrograms/g creatinine did not differ significantly from that of six age-matched non-exposed controls (2.8 +/- 1.8 mg/mmol creatinine vs. 2.3 +/- 1.6 mg/mmol creatinine, +/- S.D.) as analyzed in random urine samples. However, there was a cadmium concentration-dependent increase in the excretion of 50 kD proteoglycan as analyzed by polyacrylamide electrophoresis of the isolated proteoglycan fraction in the same urine samples. This may represent the early dose-dependent effect of cadmium on renal tubules which leads to decrease in the renal cell sialic acid content and protein excretion at higher exposure levels.
在随机采集的尿液样本分析中，五名职业性接触镉、尿镉水平为1至6.5微克/克肌酐的男性，其尿糖胺聚糖排泄量与六名年龄匹配的未接触对照组相比，无显著差异（分别为2.8±1.8毫克/毫摩尔肌酐和2.3±1.6毫克/毫摩尔肌酐，±标准差）。然而，通过对相同尿液样本中分离出的蛋白聚糖部分进行聚丙烯酰胺电泳分析发现，50 kD蛋白聚糖的排泄量随镉浓度增加而升高。这可能代表了镉对肾小管的早期剂量依赖性效应，在更高暴露水平下会导致肾细胞唾液酸含量和蛋白质排泄量降低。
