Savolainen H
Institute of Occupational Health Sciences, University of Lausanne, Switzerland.
Pharmacol Toxicol. 1994 Aug;75(2):113-4. doi: 10.1111/j.1600-0773.1994.tb00332.x.
Six foundrymen occupationally exposed to cadmium fumes excreted in random urine samples 4.8 +/- 2.9 micrograms cadmium/g creatinine (+/- S.D.). Six controls excreted 0.15 +/- 0.09 microgram/g creatinine (+/- S.D.). The excretion of glycosaminoglycans by exposed men (2.3 +/- 1.1 mg/mmol creatinine, +/- S.D.) did not differ from that of controls (2.3 +/- 1.6 mg/mmol, +/- S.D.). However, electrophoretic analysis of the isolated urinary proteoglycan fraction revealed a dose-dependent progressive increase in the intensity of two bands with a molecular weight between 45,000 and 50,000. In control urines and in samples with urinary cadmium less than 3 micrograms/g creatinine, only one major band with a molecular weight of 100,000 was detected. The changes may serve as early indicators of the harmful effects of cadmium on the proteoglycan-containing barriers of the nephron.
六名职业性接触镉烟的铸造工人随机尿样中镉的排泄量为4.8±2.9微克镉/克肌酐（±标准差）。六名对照者的排泄量为0.15±0.09微克/克肌酐（±标准差）。接触镉的男性的糖胺聚糖排泄量（2.3±1.1毫克/毫摩尔肌酐，±标准差）与对照者（2.3±1.6毫克/毫摩尔，±标准差）没有差异。然而，对分离出的尿蛋白聚糖部分进行电泳分析发现，分子量在45,000至50,000之间的两条带的强度呈剂量依赖性逐渐增加。在对照尿样和尿镉含量低于3微克/克肌酐的样本中，仅检测到一条分子量为100,000的主要带。这些变化可能作为镉对肾单位含蛋白聚糖屏障有害作用的早期指标。
