Visy J M, Vassel P, Chaine P, Woimant F, Dumas J L, Lhote F, Mainguene C, Haguenau M
Service de Neurologie, Hôpital Lariboisière, Paris.
Rev Neurol (Paris). 1993;149(6-7):428-31.
A case of HILV1-associated adult T cell leukaemia/lymphoma (ATLL) in à 21-year olf African woman is reported. The patient presented with lymphomatous meningoradiculopathy. The usual clinical features of ATLL were absent. Lumbar MRI showed a pial enhancement by DTPA-gadolinium of the conus medullaris which extended to the proximal cauda equina. Under systemic chemotherapy coupled with intrathecal chemotherapy the patient progressively improved, and at the second MRI examination complete disappearance of the lumbar enhancement was observed. MRI of the brain using axial and coronal T2-weighted sequences detected multifocal lesions of high-intensity signal in the subcortical white matter. ATLL is unusual in people of African origin. The ATLL-strongyloïdes infestation association has previously been reported, suggesting that parasitic infestation may be an important co-factor leading to the development of ATLL.
报告了一例21岁非洲女性与人类嗜T淋巴细胞病毒1型（HILV1）相关的成人T细胞白血病/淋巴瘤（ATLL）。患者表现为淋巴瘤性脑脊神经根病，缺乏ATLL的常见临床特征。腰椎磁共振成像（MRI）显示马尾圆锥有钆喷酸葡胺增强的软膜强化，并延伸至近端马尾。在全身化疗联合鞘内化疗的情况下，患者病情逐渐改善，第二次MRI检查时观察到腰椎强化完全消失。使用轴位和冠状位T2加权序列的脑部MRI检测到皮质下白质有多灶性高强度信号病变。ATLL在非洲裔人群中并不常见。此前曾有ATLL与类圆线虫感染相关的报道，提示寄生虫感染可能是导致ATLL发生的重要协同因素。
