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The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia.

作者信息

Jensen K, Freundlich M, Bünemann L, Therkelsen K, Hansen H, Cold G E

机构信息

Department of Anesthesiology Hjørring Municipal Hospital, Denmark.

出版信息

Acta Neurochir (Wien). 1993;124(2-4):114-9. doi: 10.1007/BF01401132.

DOI:10.1007/BF01401132
PMID:8304056
Abstract

In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2-4% CO2 normalized CBF.

摘要

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