Burholt D R, Hagemann R F, Schenken L L, Lesher S
Cancer Res. 1977 Jan;37(1):22-7.
The influence of adriamycin and adriamycin-radiation combinations on posttreatment proliferative activity of the mouse jejunum was examined by measuring [3H]thymidine incorporation. Single doses of 5 or 10 mg/kg produced a transient reduction in the proliferative activity, while 1 mg/kg had little effect. After 10 mg/kg, there was a rapid decrease in the number of mitotic figures, followed by a gradual decrease in the number of and rate of DNA synthesis in S-phase cells. A compensatory epithelial hyperplasia characterized by an enlarged crypt proliferative population and shortened mitotic cycle duration was observed beginning 48 hr after treatment. Multiple doses of adriamycin totalling 10 mg/kg inhibited cell production to a greater extent than the equivalent single dose. In combination with 1000 R, adriamycin (5 mg/kg) given from 96 hr before to 72 hr after irradiation reduced the amount of postirradiation proliferation.
通过测量[3H]胸腺嘧啶核苷掺入量，研究了阿霉素及阿霉素与放疗联合应用对小鼠空肠治疗后增殖活性的影响。5或10mg/kg的单剂量可使增殖活性产生短暂降低，而1mg/kg则几乎没有影响。给予10mg/kg后，有丝分裂细胞数量迅速减少，随后S期细胞的数量及DNA合成速率逐渐降低。在治疗后48小时开始观察到以隐窝增殖群体扩大和有丝分裂周期持续时间缩短为特征的代偿性上皮增生。总计10mg/kg的多次剂量阿霉素比同等单剂量更能抑制细胞产生。与1000R联合应用时，在照射前96小时至照射后72小时给予阿霉素（5mg/kg）可减少照射后增殖量。
