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Selective inhibition of dihydrofolate reductase from problem human pathogens.

作者信息

Then R L, Hartman P G, Kompis I, Santi D

机构信息

F. Hoffmann-La Roche Ltd, Basel/Switzerland.

出版信息

Adv Exp Med Biol. 1993;338:533-6. doi: 10.1007/978-1-4615-2960-6_108.

DOI:10.1007/978-1-4615-2960-6_108
PMID:8304174
Abstract
摘要

相似文献

1
Selective inhibition of dihydrofolate reductase from problem human pathogens.
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2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine analogues of trimethoprim as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.甲氧苄啶的2,4-二氨基-6,7-二氢-5H-环戊并[d]嘧啶类似物作为卡氏肺孢子虫和刚地弓形虫二氢叶酸还原酶的抑制剂
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引用本文的文献

1
Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors.三甲氧苄氨嘧啶和其他非经典抗叶酸类药物是寻找二氢叶酸还原酶抑制剂修饰物的绝佳模板。
J Antibiot (Tokyo). 2020 Jan;73(1):5-27. doi: 10.1038/s41429-019-0240-6. Epub 2019 Oct 2.
2
Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.在卡氏肺孢子虫生长的培养模型中对二氢叶酸还原酶强效抑制剂的评估。
Antimicrob Agents Chemother. 1995 Nov;39(11):2436-41. doi: 10.1128/AAC.39.11.2436.
3
Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
二氨基喹唑啉及其他卡氏肺孢子虫和刚地弓形虫二氢叶酸还原酶抑制剂的构效关系和构选关系研究
Antimicrob Agents Chemother. 1995 Jan;39(1):79-86. doi: 10.1128/AAC.39.1.79.