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Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).

作者信息

Pavlovic M, Leffert J J, Russello O, Bunni M A, Beardsley G P, Priest D G, Pizzorno G

机构信息

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.

出版信息

Adv Exp Med Biol. 1993;338:775-8. doi: 10.1007/978-1-4615-2960-6_162.

DOI:10.1007/978-1-4615-2960-6_162
PMID:8304227
Abstract
摘要

相似文献

1
Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).在一株对（6R）5,10-二去氮四氢叶酸（DDATHF）耐药的人白血病细胞系中，叶酸和抗叶酸剂通过载体介导的还原型叶酸转运系统的转运发生改变。
Adv Exp Med Biol. 1993;338:775-8. doi: 10.1007/978-1-4615-2960-6_162.
2
Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport.
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5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines.5,10-二去氮四氢叶酸（DDATHF）在CCRF-CEM和MA104细胞系中的转运
J Biol Chem. 1993 Jan 15;268(2):1017-23.
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Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.具有与转运相关的甲氨蝶呤耐药性的人乳腺癌细胞中膜叶酸受体的功能方面
Cancer Chemother Pharmacol. 1996;38(3):281-8. doi: 10.1007/s002800050483.
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Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro.膜叶酸结合蛋白在5,10-二去氮四氢叶酸对人卵巢癌细胞系体外细胞毒性中的作用
Br J Cancer. 1996 Feb;73(4):525-30. doi: 10.1038/bjc.1996.91.
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Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.甲氨蝶呤敏感和耐药白血病细胞中载体介导的叶酸和抗叶酸转运的调节
Adv Enzyme Regul. 1997;37:59-76. doi: 10.1016/s0065-2571(96)00012-x.
7
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.（6R）-5,10-二去氮-5,6,7,8-四氢叶酸和甲氨蝶呤对人淋巴细胞白血病细胞具有不同抗肿瘤活性的决定因素，其特征为抗叶酸膜转运严重受损。
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8
Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.在表达高水平膜相关叶酸结合蛋白的人KB细胞中鉴定出一种还原型叶酸/甲氨蝶呤载体。
Adv Exp Med Biol. 1993;338:771-4. doi: 10.1007/978-1-4615-2960-6_161.
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The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships.还原型叶酸/甲氨蝶呤载体及一种膜相关叶酸结合蛋白作为新型抗叶酸药物的转运途径：构效关系
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Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.甲氨蝶呤耐药性人乳腺癌细胞系中的叶酸转运及抗叶酸敏感性调节
Cancer Commun. 1991;3(12):357-65. doi: 10.3727/095535491820873687.

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