Anandakumar C, Annapoorna V, Chee W Y, Chia D, Bongso A, Ratnam S S
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Aust N Z J Obstet Gynaecol. 1993 Aug;33(3):259-61. doi: 10.1111/j.1479-828x.1993.tb02080.x.
A prospective study on fetal blood sampling (FBS) was conducted in the Fetomaternal Medicine Division of the Department of Obstetrics and Gynaecology at the National University Hospital, Singapore. FBS was performed on 159 occasions in 156 women between January, 1988 and December, 1991. The aim of this study was to identify the factors that were associated with an adverse outcome following the procedure. Twenty four abnormal pregnancies were terminated; of the remaining 132 desired pregnancies the overall pregnancy loss was 44 (33.3%), which included those within 2 weeks and those after 2 weeks of the procedure and neonatal deaths. Fetal loss occurring within 2 weeks of the procedure is considered a procedure-related loss which occurred in 19 (14.3%) of the 132 pregnancies. When the fetal loss occurred within 2 weeks of the procedure 89% had a major abnormality on ultrasonographic scanning. The conclusion from our study is that the risks of FBS were increased in abnormal pregnancies, most likely due to the underlying pathology.
新加坡国立大学医院妇产科母胎医学科对胎儿血样采集（FBS）进行了一项前瞻性研究。1988年1月至1991年12月期间，对156名女性进行了159次胎儿血样采集。本研究的目的是确定与该操作后不良结局相关的因素。24例异常妊娠被终止；在其余132例期望妊娠中，总体妊娠丢失为44例（33.3%），其中包括操作后2周内和2周后的妊娠丢失以及新生儿死亡。操作后2周内发生的胎儿丢失被视为与操作相关的丢失，在132例妊娠中有19例（14.3%）发生。当胎儿丢失发生在操作后2周内时，89%的胎儿在超声扫描时有严重异常。我们研究的结论是，异常妊娠中胎儿血样采集的风险增加，最可能是由于潜在的病理状况。
