Myers M G, Wisenberg G
Chest. 1977 Jan;71(1):24-6. doi: 10.1378/chest.71.1.24.
On 51 of 53 occasions, sudden withdrawal of propranolol from patients with angina pectoris produced no substantial adverse effects. Two patients experienced a recurrence of unstable angina with one man sustaining a fatal myocardial infarction ten days after propranolol withdrawal. These observations suggest that patients with previous unstable angina may be dependent upon beta-adrenoceptor blockade. Sudden cessation of propranolol for short periods may be preferable to tapering the dosage if prolonged periods of sub-optimal beta-adrenoceptor blockade are to be avoided.
在53例中有51例，心绞痛患者突然停用普萘洛尔未产生重大不良反应。两名患者出现不稳定型心绞痛复发，其中一名男性在停用普萘洛尔十天后发生致命性心肌梗死。这些观察结果表明，既往有不稳定型心绞痛的患者可能依赖β-肾上腺素能受体阻滞剂。如果要避免长时间的次优β-肾上腺素能受体阻滞，短期内突然停用普萘洛尔可能比逐渐减少剂量更可取。
