Kiyingi K S, Shaw J
Eur J Clin Pharmacol. 1984;27(4):423-8. doi: 10.1007/BF00549589.
A study was carried out to determine whether beta-adrenergic hypersensitivity occurs in normal subjects following the abrupt withdrawal of the beta-adrenoceptor antagonist propranolol. Sixteen normal subjects took propranolol, orally, 120 mg twice daily for one week. Heart rate and blood pressure were measured supine and standing as well as during exercise. Heart rate was measured during and following the Valsalva manoeuvre. Measurements were made on the last day of the treatment period and on two occasions during the six days following withdrawal. Three subjects were removed from the analysis because of failure to take medication and one more was excluded because of protocol variation. In the remaining twelve, propranolol treatment reduced all parameters measured. Following abrupt withdrawal of the drug, there was no measurable increase in any of the parameters above baseline or placebo values within six days of the withdrawal. These findings, from normal subjects, do not support the phenomenon of beta-adrenergic hypersensitivity following propranolol withdrawal.
开展了一项研究，以确定在正常受试者突然停用β-肾上腺素能受体拮抗剂普萘洛尔后是否会发生β-肾上腺素能超敏反应。16名正常受试者口服普萘洛尔，每日两次，每次120mg，持续一周。测量了仰卧位、站立位以及运动期间的心率和血压。在瓦尔萨尔瓦动作期间及之后测量心率。在治疗期的最后一天以及停药后的六天内进行了两次测量。三名受试者因未服药而被排除在分析之外，另有一名因方案差异而被排除。在其余12名受试者中，普萘洛尔治疗降低了所有测量参数。突然停药后，停药后六天内，上述任何参数均未出现超过基线或安慰剂值的可测量增加。这些来自正常受试者的研究结果不支持普萘洛尔停药后出现β-肾上腺素能超敏反应的现象。
