Dolara P, Caderni G, Bianchini F, Luceri C, Spagnesi M T, Testolin G
Department of Pharmacology, University of Florence, Firenze, Italy.
Basic Life Sci. 1993;61:437-45. doi: 10.1007/978-1-4615-2984-2_38.
The effect of dietary starch and sucrose on colon proliferation and the growth of foci of dysplastic crypts in the colon (FDC) were studied in female Sprague-Dawley rats, treated p.o. with 1,2-dimethylhydrazine (DMH). The animals were fed for 30 and 105 days with high fat (23% w/w corn oil) diets in which carbohydrates were represented by corn starch (starch diet) or sucrose (sucrose diet) (46% w/w). After 105 days of feeding, proliferation was markedly reduced in animals fed the starch diet. The number of FDC was not significantly affected by dietary treatments. However, after 30 and 105 days the percent of small FDC (formed by one-two dysplastic crypts) was higher in the animals fed the starch diet when compared to the sucrose diet. In the cecum of the animals fed the starch diet the percent of butyrate, propionic, isovaleric, and valeric over total short-chain fatty acids (SCFA) was increased, whereas the percent of acetic acid was decreased. Cecal pH was also decreased in the animals fed starch. The results suggest that starch diets have a protective role against DMH-colon carcinogenesis in the rat, mediated by a drop in cecal pH and an increased concentration of some SCFA.
在经口给予1,2 - 二甲基肼（DMH）处理的雌性斯普拉格 - 道利大鼠中，研究了膳食淀粉和蔗糖对结肠增殖以及结肠发育异常隐窝灶（FDC）生长的影响。给动物喂食高脂肪（23% w/w玉米油）饮食30天和105天，其中碳水化合物分别由玉米淀粉（淀粉饮食）或蔗糖（蔗糖饮食）提供（46% w/w）。喂食105天后，喂食淀粉饮食的动物的增殖显著降低。膳食处理对FDC的数量没有显著影响。然而，与蔗糖饮食相比，喂食淀粉饮食的动物在30天和105天后，小FDC（由一两个发育异常隐窝形成）的百分比更高。在喂食淀粉饮食的动物的盲肠中，丁酸、丙酸、异戊酸和戊酸占总短链脂肪酸（SCFA）的百分比增加，而乙酸的百分比降低。喂食淀粉的动物的盲肠pH值也降低。结果表明，淀粉饮食对大鼠DMH诱导的结肠癌发生具有保护作用，这是由盲肠pH值下降和一些SCFA浓度增加介导的。
