Beach F A, Buehler M G
Endocrinology. 1977 Jan;100(1):197-200. doi: 10.1210/endo-100-1-197.
Pseudohermaphroditic Stanley-Gumbreck male rats showed infrequent and incomplete copulatory responses to receptive females. Administration of testosterone propionate produced no increase in this behavior. Injections of estradiol and progesterone induced the pseudohermaphrodites to exhibit lordosis when mounted by stimulus males, but feminine responses were no more frequent than those of normal males given the same hormonal treatment. The hypothesis is suggested that early in development sufficient endogenous testis hormone is produced to cause normal desensitization of feminine behavioral mechanisms to estradiol, but that mechanisms for male behavior are not normally sensitized to testosterone.
假性两性畸形的斯坦利-冈布雷克雄性大鼠对处于发情期的雌性表现出的交配反应很少且不完整。注射丙酸睾酮后，这种行为并未增加。给假性两性畸形大鼠注射雌二醇和孕酮后，当有刺激雄性大鼠与之交配时，它们会表现出脊柱前凸，但与接受相同激素处理的正常雄性大鼠相比，雌性化反应的频率并没有更高。由此提出一个假说：在发育早期，机体产生了足够的内源性睾丸激素，使雌性行为机制对雌二醇产生正常的脱敏作用，但雄性行为机制通常不会对睾酮产生敏感化。
