Gladkova A I, Karpenko N A
Farmakol Toksikol. 1986 Jan-Feb;49(1):33-7.
Sexual behaviour was tested in female rats with ovariectomy treated with various sexual hormones and healthy male rats with sexual experience. There was a marked suppression of receptive behaviour in rats with ovariectomy but the proceptive one was preserved. A marked growth of lordosis, achieving the level of that in intact rats in estrus is observed after the administration of estradiol propionate (10 micrograms) and progesterone (500 micrograms). A single subcutaneous administration of testosterone dipropionate (100 micrograms) and dihydrotestosterone (DHT) with DHT-propionate (10 micrograms) to ovariectomized rats did not stimulate lordosis but preserved a high level of proceptive behaviour. Disconnections in the character of proceptive and mating behaviour show that different mechanisms are in the base of their regulation. No difference was noted in the effect of testosterone and DHT on sexual behaviour. The administration of DHT induced certain aggressiveness in the animals. No dynamics was observed in the character of the studied indicators for 3 days. The lack of differences in testosterone and DHT action on sexual behaviour of female rats shows that intracerebral aromatization is not obligatory for the manifestation of the effect.
对接受各种性激素治疗的去卵巢雌性大鼠和有性经验的健康雄性大鼠进行性行为测试。去卵巢大鼠的接受行为受到明显抑制，但求偶行为得以保留。给予丙酸雌二醇（10微克）和孕酮（500微克）后，观察到弓背行为显著增加，达到完整大鼠发情期的水平。对去卵巢大鼠单次皮下注射丙酸睾酮（100微克）和二氢睾酮（DHT）与丙酸DHT（10微克），并未刺激弓背行为，但保留了高水平的求偶行为。求偶行为和交配行为特征的脱节表明，它们的调节基于不同机制。睾酮和DHT对性行为的影响未观察到差异。DHT的给药在动物中诱导了一定的攻击性。在3天内未观察到所研究指标特征的动态变化。睾酮和DHT对雌性大鼠性行为作用缺乏差异表明，脑内芳香化作用并非效应表现所必需。
