Bakker A J, Gorgels J P, van Vlies B, Haagen F D, Smits R
Department of Clinical Chemistry, Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands.
Eur J Clin Chem Clin Biochem. 1993 Nov;31(11):715-24. doi: 10.1515/cclm.1993.31.11.715.
The time-related frequency of elevated results for the mass concentrations of the MB isoenzyme of creatine kinase and of troponin T were compared with that of creatine kinase and creatine kinase-MB activity in patients with acute myocardial infarction. Patients (322; 175 with and 147 without myocardial infarction) consecutively admitted for evaluation of possible acute myocardial infarction were investigated. Reference limits for troponin T (0.1 microgram/l) and creatine kinase-MB mass concentration (5.0 micrograms/l) were exceeded frequently in patients with unstable angina pectoris (troponin T 43%, creatine kinase-MB mass concentration 24%) in contrast to patients with no acute ischaemic heart disease (both < 5%). Within 4 and between 4-8 hours after onset of chest pain, the frequency of elevated results for creatine kinase-MB mass concentration and troponin T in patients with acute myocardial infarction was considerably higher (20-30%) than for creatine kinase and creatine kinase-MB activity. Creatine kinase-MB mass concentration and troponin T both allowed earlier diagnosis of acute myocardial infarction than creatine kinase and creatine kinase-MB activity, but troponin T was not elevated before the creatine kinase-MB mass concentration.
将急性心肌梗死患者中肌酸激酶MB同工酶和肌钙蛋白T质量浓度升高结果的时间相关频率与肌酸激酶及肌酸激酶MB活性的时间相关频率进行了比较。对连续收治以评估可能急性心肌梗死的患者（共322例，其中175例有心肌梗死，147例无心肌梗死）进行了调查。与无急性缺血性心脏病的患者（两者均<5%）相比，不稳定型心绞痛患者中肌钙蛋白T（0.1微克/升）和肌酸激酶MB质量浓度（5.0微克/升）的参考限值经常被超过（肌钙蛋白T为43%，肌酸激酶MB质量浓度为24%）。在胸痛发作后4小时内以及4 - 8小时之间，急性心肌梗死患者中肌酸激酶MB质量浓度和肌钙蛋白T升高结果的频率显著高于肌酸激酶及肌酸激酶MB活性（20 - 30%）。与肌酸激酶及肌酸激酶MB活性相比，肌酸激酶MB质量浓度和肌钙蛋白T均能更早诊断急性心肌梗死，但肌钙蛋白T在肌酸激酶MB质量浓度升高之前并未升高。
