Foster B C, Litster D L, Buttar H S, Dawson B, Zamecnik J
Bureau of Drug Research, Sir Frederick Banting Research Centre, Ottawa, Ontario, Canada.
Biopharm Drug Dispos. 1993 Nov;14(8):709-19. doi: 10.1002/bdd.2510140807.
The urinary elimination of 4-hydroxyamphetamine (PHA) and a series of homologous 4-alkoxy-substituted amphetamines and their metabolites was examined after single and multiple oral administration to pregnant and non-pregnant mice. The metabolic profile and extent of biotransformation in a series of alkoxy analogues were affected by the size of the alkoxy side chain, multiple dosing and pregnancy. There were increased recoveries of both the substrate and the conjugated derivative of PHA during gestation. The major metabolic routes observed were O-dealkylation, conjugation, and aliphatic hydroxylation of the propoxy side chain. There was some evidence of oxidative deamination. Pregnancy did not alter the profile of the major metabolites detected by GLC and NMR spectroscopy.
在对怀孕和未怀孕的小鼠进行单次和多次口服给药后，检测了4-羟基苯丙胺（PHA）以及一系列同源的4-烷氧基取代苯丙胺及其代谢产物的尿排泄情况。一系列烷氧基类似物的代谢谱和生物转化程度受烷氧基侧链大小、多次给药和怀孕的影响。在妊娠期间，PHA的底物及其结合衍生物的回收率均有所增加。观察到的主要代谢途径为O-脱烷基化、结合以及丙氧基侧链的脂肪族羟基化。有一些氧化脱氨基的证据。怀孕并未改变通过气相色谱法（GLC）和核磁共振光谱法（NMR）检测到的主要代谢产物的谱图。
