Ansai S, Koseki S, Hozumi Y, Tsunoda T, Yuda F
Department of Dermatology, Yamagata University, Faculty of Medicine, Japan.
Dermatology. 1994;188(1):57-61. doi: 10.1159/000247088.
A case of malignant hidroacanthoma simplex of the anterior aspect of the right ankle in a 75-year-old man is reported. A specimen obtained in 1987 showed the features of benign hidroacanthoma simplex, whereas that taken in 1991 revealed malignant transformation. We performed immunohistochemical studies on these two specimens, and they suggest this tumor derives from the outer cells of intraepidermal ducts. The proliferating cell nuclear antigen labelling index and argyrophil nucleolar organizer regions of these two specimens were also compared and correlated with malignant transformation.
报告了一例75岁男性右踝前部单纯性恶性汗腺棘皮瘤。1987年获取的标本显示为良性单纯性汗腺棘皮瘤特征，而1991年获取的标本则显示有恶性转化。我们对这两个标本进行了免疫组织化学研究，结果提示该肿瘤起源于表皮内导管的外层细胞。还比较了这两个标本的增殖细胞核抗原标记指数和嗜银核仁组成区，并将其与恶性转化相关联。
