文字众多，科学却少：对37年依地酸钠螯合疗法文献的综述
So much writing, so little science: a review of 37 years of literature on edetate sodium chelation therapy.
作者信息
Grier M T, Meyers D G
机构信息
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198.
出版信息
Ann Pharmacother. 1993 Dec;27(12):1504-9. doi: 10.1177/106002809302701217.
OBJECTIVE
To determine the safety and efficacy of edetate sodium (ethylenediamine tetraacetic acid; EDTA) chelation therapy for atherosclerosis.
METHODS
Literature search using MEDLINE, encompassing 1966 through May 1993. Further references were obtained from articles and books, and from citations obtained from the American Academy of Medical Preventics.
RESULTS
16 case reports or case series, 2 longitudinal studies, and 3 clinical trials were reviewed, along with testimonials cited in 19 books.
CONCLUSIONS
Little valid scientific evidence is available. Although the postulated mechanisms of action for EDTA are biologically plausible and EDTA appears to be safe, it has not been proven effective. Indeed, the best evidence shows it to be ineffective. Therefore, EDTA chelation therapy should not be used in clinical practice to treat atherosclerosis.
目的
确定依地酸钠（乙二胺四乙酸；EDTA）螯合疗法治疗动脉粥样硬化的安全性和有效性。
方法
使用MEDLINE进行文献检索，涵盖1966年至1993年5月。通过文章、书籍以及从美国医学预防学会获得的参考文献获取更多资料。
结果
回顾了16篇病例报告或病例系列、2项纵向研究和3项临床试验，以及19本书中引用的推荐案例。
结论
几乎没有有效的科学证据。尽管EDTA假定的作用机制在生物学上看似合理，且EDTA似乎是安全的，但尚未证明其有效。实际上，最有力的证据表明它无效。因此，EDTA螯合疗法不应在临床实践中用于治疗动脉粥样硬化。
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