Piscitelli S C, Occhipinti D J, Danziger L H, Hill C, West D P, Fischer J H
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago 60612.
Ann Pharmacother. 1993 Dec;27(12):1526-31. doi: 10.1177/106002809302701220.
To describe the role of the clinical pharmacist in a Hansen's disease (HD, leprosy) clinic and to describe the development, validation, and operation of a dapsone compliance monitoring program.
HD remains a major, worldwide healthcare problem. Dapsone is the drug of choice for treatment of HD; however, high rates of noncompliance with this agent have been reported by many treatment centers. The assessment of compliance in HD patients is important to help distinguish between treatment failure secondary to noncompliance or to the development of resistance.
In the US, the Chicago Regional Hansen's Disease Center at the University of Illinois at Chicago is one of ten centers that provide comprehensive care to patients diagnosed with this condition. This article reviews the clinical pharmacy services and dapsone compliance program in the clinic encompassing the years 1983-93.
The clinical pharmacist provides a variety of clinical services in the clinic as well as coordinating the clinical research program. A pharmacist-generated dapsone compliance program led to improvement in compliance rates and clinical outcome. This improvement in compliance has been sustained over an extended period of time.
The clinical pharmacy services performed in the HD clinic provide a model for pharmacy involvement in other chronic disease states. The dapsone compliance program has been successful in improving patient care and obtaining reimbursement for clinical pharmacy services.
描述临床药师在麻风病诊所中的作用，并描述氨苯砜依从性监测项目的开发、验证和运行情况。
麻风病仍是一个全球性的重大医疗问题。氨苯砜是治疗麻风病的首选药物；然而，许多治疗中心报告该药物的不依从率很高。评估麻风病患者的依从性对于区分因不依从或耐药性发展导致的治疗失败很重要。
在美国，位于芝加哥伊利诺伊大学的芝加哥地区麻风病中心是为诊断为此病的患者提供全面护理的十个中心之一。本文回顾了1983年至1993年该诊所的临床药学服务和氨苯砜依从性项目。
临床药师在诊所提供各种临床服务，并协调临床研究项目。由药师制定的氨苯砜依从性项目提高了依从率和临床疗效。这种依从性的改善在很长一段时间内得以维持。
麻风病诊所开展的临床药学服务为药学参与其他慢性病治疗提供了一个模式。氨苯砜依从性项目成功改善了患者护理，并为临床药学服务获得了报销。
