Piscitelli S C, Danziger L H, Hill C, Slajchert A A, West D P, Fischer J H
Department of Pharmacy Practice, Chicago Regional Hansen's Disease Center, University of Illinois.
Int J Dermatol. 1993 Mar;32(3):206-9. doi: 10.1111/j.1365-4362.1993.tb02797.x.
Long-term effectiveness of a dapsone compliance program was assessed in patients with leprosy.
The monitoring program consists of urine dapsone/creatinine ratio determination at each visit with subsequent patient feedback and education. Eighty-eight patients receiving dapsone and seen in a leprosy clinic from 1985-1990 were included.
The proportion of patients compliant with dapsone during a given year ranged from 70.0% (1987) to 94.4% (1989). Overall compliance for the 6-year period was 81.6%. This level of compliance was significantly different (P < 0.05) than the baseline compliance in the leprosy clinic of 46.7%.
Compliance monitoring, combined with active patient involvement, was effective in sustaining high compliance over a 6-year period.
对麻风病患者的氨苯砜依从性计划的长期有效性进行了评估。
监测计划包括在每次就诊时测定尿氨苯砜/肌酐比值，随后对患者进行反馈和教育。纳入了1985年至1990年期间在麻风病诊所接受氨苯砜治疗的88例患者。
在给定年份中，氨苯砜治疗依从性患者的比例从70.0%（1987年）到94.4%（1989年）不等。6年期间的总体依从率为81.6%。这一依从水平与麻风病诊所46.7%的基线依从率相比有显著差异（P<0.05）。
依从性监测，结合患者的积极参与，在6年期间有效地维持了高依从率。
