Escolar J D, Mateos J, Alfaro E, Escolar M A, Miñana C, Roche P
Department of Morphological Science, Faculty of Medicine, Zaragoza, Spain.
Histol Histopathol. 1993 Oct;8(4):609-15.
The following hypothesis is suggested: if a lung disease is induced in an adult rat, then its lung, in the senile age, will be different from what is considered to be a normal senile lung. In order to demonstrate this, the pulmonary state of two groups of old rats, one of which had suffered from Goodpasture's syndrome in the adult age has been assessed morphometrically. Fifty-three Wistar rats were used. They were divided into two groups: 1) healthy old rats; and 2) diseased old rats. Antipulmonary serum was administered to the latter and they were sacrificed a year later. Making use of a computing system, we calculated the following data for each group: the alveolar chord length, the alveolar wall thickness and the surface of the bronchial-associated lymphoid tissue (BALT). The alveolar macrophages (AM) with haemosiderin which were found in the lung tissue were also counted and the percentage of goblet bronchial cells and that of bronchoalveolar lavage (BAL) cells was also assessed. From the results, the following points should be emphasized: in diseased old rats, an increase in the alveolar chord, a decrease in lymphocytes with an increase in the AM of the BAL, and a decrease in goblet cells and AM with haemosiderin occur, all of which are significant when these rats are compared to healthy old rats.(ABSTRACT TRUNCATED AT 250 WORDS)
如果在成年大鼠中诱发肺部疾病，那么其老年时的肺将与被认为是正常老年肺的情况不同。为了证明这一点，对两组老年大鼠的肺部状态进行了形态计量学评估，其中一组在成年时患有古德帕斯丘综合征。使用了53只Wistar大鼠。它们被分为两组：1）健康老年大鼠；2）患病老年大鼠。给后者注射抗肺血清，一年后将它们处死。利用计算机系统，我们为每组计算了以下数据：肺泡弦长、肺泡壁厚度和支气管相关淋巴组织（BALT）的表面积。还对肺组织中发现的含铁血黄素肺泡巨噬细胞（AM）进行了计数，并评估了杯状支气管细胞和支气管肺泡灌洗（BAL）细胞的百分比。从结果来看，应强调以下几点：在患病老年大鼠中，肺泡弦增加，BAL中淋巴细胞减少而AM增加，杯状细胞和含铁血黄素AM减少，与健康老年大鼠相比，所有这些差异都具有显著性。（摘要截短至250字）
