Zhao M, Laissue J A, Zimmermann A
Institute of Pathology of the University, Bern, Switzerland.
Histol Histopathol. 1993 Oct;8(4):617-26.
We have analyzed neuroendocrine differentiation (ND) in hepatocellular carcinomas (HCCs) of fifty patients. It turned out that ND is frequent in HCCs, and that it is not restricted to fibrolamellar hepatocellular carcinoma (FL-HCC). Multiexpression is seen in a quarter of the cases, and marker coexpression may occur within the same tumor cell. ND predominates in trabecular and mixed HCCs, but does not appear to be related to grade. Most positive cases showed a hepatocyte-like cell morphology, frequently associated with bile formation. It thus appears that the HCC cell type most likely to show ND is a hepatocyte-like one, i.e. differentiated cell, frequently polarized and producing bile, rather than a small and poorly-differentiated cell. Possible pathogenic mechanisms leading to ND in HCCs are briefly discussed.
我们分析了50例肝细胞癌（HCC）中的神经内分泌分化（ND）情况。结果表明，ND在HCC中很常见，且不限于纤维板层肝细胞癌（FL - HCC）。四分之一的病例出现多表达，且标记物共表达可能发生在同一肿瘤细胞内。ND在小梁状和混合型HCC中占主导，但似乎与分级无关。大多数阳性病例呈现肝细胞样细胞形态，常与胆汁形成有关。因此，最有可能表现出ND的HCC细胞类型似乎是肝细胞样细胞，即分化细胞，常呈极化状态并产生胆汁，而非小的低分化细胞。文中简要讨论了HCC中导致ND的可能致病机制。
