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2
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3
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Stable adenine nucleotides inhibit [3H]-noradrenaline release in rabbit brain cortex slices by direct action at presynaptic adenosine A1-receptors.稳定的腺嘌呤核苷酸通过直接作用于突触前腺苷A1受体来抑制兔脑皮质切片中[3H]-去甲肾上腺素的释放。
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9
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J Pharmacol Exp Ther. 1991 Mar;256(3):821-6.
10
A1 adenosine receptor modulation of electrically-evoked contractions in the bisected vas deferens and cauda epididymis of the guinea-pig.豚鼠输精管和附睾尾部电诱发收缩的A1腺苷受体调节
Br J Pharmacol. 1998 Jul;124(5):964-70. doi: 10.1038/sj.bjp.0701909.

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8
ATP-evoked increases in [Ca2+]i and peptide release from rat isolated neurohypophysial terminals via a P2X2 purinoceptor.三磷酸腺苷（ATP）通过P2X2嘌呤受体引起大鼠离体神经垂体终末内钙离子浓度（[Ca2+]i）升高及肽类释放。
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Blockade by 4,4'-diisothiocyanatostilbene-2,2'-disulphonate (DIDS) of P2X-purinoceptors in rat vas deferens.4,4'-二异硫氰基芪-2,2'-二磺酸盐（DIDS）对大鼠输精管中P2X嘌呤受体的阻断作用
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本文引用的文献

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Axon terminal P2-purinoceptors in feedback control of sympathetic transmitter release.轴突终末P2嘌呤受体在交感神经递质释放的反馈控制中发挥作用。
Neuroscience. 1993 Sep;56(2):263-7. doi: 10.1016/0306-4522(93)90330-i.
2
Modulation of the vasoconstrictor response to adrenergic stimulation by nucleosides and nucleotides.核苷和核苷酸对肾上腺素能刺激引起的血管收缩反应的调节作用。
J Pharmacol Exp Ther. 1982 Aug;222(2):344-9.
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Pharmacological characterization of purinergic receptors in the rat vas deferens.大鼠输精管中嘌呤能受体的药理学特性
J Pharmacol Exp Ther. 1983 Jan;224(1):40-5.
4
Modulation of neurotransmission by purine nucleotides and nucleosides.嘌呤核苷酸和核苷对神经传递的调节。
Biochem Pharmacol. 1980 Jun 15;29(12):1635-43. doi: 10.1016/0006-2952(80)90117-3.
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Physiological roles for adenosine and adenosine 5'-triphosphate in the nervous system.腺苷和三磷酸腺苷在神经系统中的生理作用。
Neuroscience. 1981;6(4):523-55. doi: 10.1016/0306-4522(81)90145-7.
6
Vascular and metabolic effects of theophylline, dibuturyl cyclic AMP and dibuturyl cyclic GMP in canine subcutaneous adipose tissue in situ.茶碱、二丁酰环磷腺苷和二丁酰环磷鸟苷对犬皮下脂肪组织原位血管及代谢的影响
Acta Physiol Scand. 1974 Jan;90(1):226-36. doi: 10.1111/j.1748-1716.1974.tb05581.x.
7
The activity of phosphorothioate analogues of ATP in various smooth muscle systems.ATP的硫代磷酸酯类似物在各种平滑肌系统中的活性。
Br J Pharmacol. 1985 Jan;84(1):165-73.
8
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes.A1选择性腺苷拮抗剂8-环戊基-1,3-二丙基黄嘌呤与大鼠脑膜的结合。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. doi: 10.1007/BF00165037.
9
A study of the actions of P1-purinoceptor agonists and antagonists in the mouse vas deferens in vitro.一项关于P1嘌呤受体激动剂和拮抗剂对小鼠离体输精管作用的研究。
Br J Pharmacol. 1988 May;94(1):37-46. doi: 10.1111/j.1476-5381.1988.tb11497.x.
10
Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.苏拉明：小鼠输精管中的一种可逆性P2嘌呤受体拮抗剂。
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小鼠和大鼠输精管中去甲肾上腺素释放的接头前调节：P1和P2嘌呤受体的作用

Prejunctional modulation of noradrenaline release in mouse and rat vas deferens: contribution of P1- and P2-purinoceptors.

作者信息

Kurz K, von Kügelgen I, Starke K

机构信息

Pharmakologisches Institut, Freiburg, Germany.

出版信息

Br J Pharmacol. 1993 Dec;110(4):1465-72. doi: 10.1111/j.1476-5381.1993.tb13986.x.

DOI:10.1111/j.1476-5381.1993.tb13986.x
PMID:8306088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2175891/
Abstract
  1. Prejunctional purinoceptors modulating the release of noradrenaline were compared in mouse and rat vas deferens. Tissue slices were preincubated with [3H]-noradrenaline and then superfused and stimulated electrically, in most experiments by trains of 60 pulses, 1 Hz. 2. In mouse vas deferens, 2-chloroadenosine (IC50 0.24 microM), beta,gamma-methylene-ATP (IC50 3.8 microM), alpha,beta-methylene-ATP (IC50 2.9 microM) and 2-methylthio-ATP (only 30 microM tested) reduced the evoked overflow of tritium. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), 10 nM, antagonized the effect of 2-chloro-adenosine (apparent pKB 10.2) as well as of beta,gamma-methylene-ATP (apparent pKB 9.6) and alpha,beta-methylene-ATP. Suramin, 300 microM, attenuated the effect of 2-chloroadenosine at best very slightly, antagonized the effect of beta,gamma-methylene-ATP (apparent pKB 4.5) and, when combined with DPCPX 10 nM, caused a further marked shift to the right of the concentration-response curve of beta,gamma-methylene-ATP beyond the shift produced by DPCPX alone. 3. In rat vas deferens, 2-chloroadenosine (IC50 0.20 microM), beta,gamma-methylene-ATP (IC50 4.8 microM), alpha,beta-methylene-ATP (IC50 3.0 microM) and 2-methylthio-ATP (only 30 microM tested) also reduced the evoked overflow of tritium. DPCPX, 10 nM, antagonized the effect of 2-chloroadenosine (apparent pKB 9.7) as well as of beta,gamma-methylene-ATP (apparent pKB 9.6) and alpha,beta-methylene-ATP. Suramin, 300 microM, did not change the effect of 2-chloroadenosine, attenuated the effect of beta,gamma-methylene-ATP at best very slightly and, when combined with DPCPX, caused at best a very small shift to the right of the concentration-response curve of beta,gamma-methylene-ATP beyond the shift produced by DPCPX alone.4. It is concluded that prejunctional purinoceptor mechanisms in mouse and rat vas deferens are similar. In either species, both nucleosides such as adenosine and nucleotides such as beta,gamma-methylene-ATP activate a common release-inhibiting receptor which is a Pl- or, more specifically, A1-purinoceptor.There seems to be no need to postulate the existence of a novel prejunctional P3-purinoceptor.Moreover, the sympathetic terminal axons possess an additional P2-purinoceptor in both species which is activated by some nucleotides such as beta,gamma-methylene-ATP and 2-methylthio-ATP, although the activation of the P2-purinoceptor by beta,gamma-methylene-ATP is difficult to demonstrate in the rat.
摘要

  1. 对小鼠和大鼠输精管中调节去甲肾上腺素释放的接头前嘌呤受体进行了比较。组织切片先用[3H] - 去甲肾上腺素预孵育，然后进行灌流并电刺激，在大多数实验中采用1 Hz的60个脉冲串刺激。

  2. 在小鼠输精管中，2 - 氯腺苷（IC50 0.24 microM）、β,γ - 亚甲基 - ATP（IC50 3.8 microM）、α,β - 亚甲基 - ATP（IC50 2.9 microM）和2 - 甲硫基 - ATP（仅测试了30 microM）减少了诱发的氚溢出。10 nM的8 - 环戊基 - 1,3 - 二丙基黄嘌呤（DPCPX）拮抗2 - 氯腺苷（表观pKB 10.2）以及β,γ - 亚甲基 - ATP（表观pKB 9.6）和α,β - 亚甲基 - ATP的作用。300 microM的苏拉明对2 - 氯腺苷的作用至多仅有非常轻微的减弱，拮抗β,γ - 亚甲基 - ATP的作用（表观pKB 4.5），并且当与10 nM的DPCPX联合使用时，使β,γ - 亚甲基 - ATP的浓度 - 反应曲线进一步显著右移，超出单独使用DPCPX所产生的右移。

  3. 在大鼠输精管中，2 - 氯腺苷（IC50 0.20 microM）、β,γ - 亚甲基 - ATP（IC50 4.8 microM）、α,β - 亚甲基 - ATP（IC50 3.0 microM）和2 - 甲硫基 - ATP（仅测试了30 microM）也减少了诱发的氚溢出。10 nM的DPCPX拮抗2 - 氯腺苷（表观pKB 9.7）以及β,γ - 亚甲基 - ATP（表观pKB 9.6）和α,β - 亚甲基 - ATP的作用。300 microM的苏拉明不改变2 - 氯腺苷的作用，对β,γ - 亚甲基 - ATP的作用至多仅有非常轻微的减弱，并且当与DPCPX联合使用时，使β,γ - 亚甲基 - ATP的浓度 - 反应曲线至多仅有非常小的右移，超出单独使用DPCPX所产生的右移。

  4. 得出的结论是，小鼠和大鼠输精管中的接头前嘌呤受体机制相似。在这两个物种中，腺苷等核苷和β,γ - 亚甲基 - ATP等核苷酸都激活一种共同的释放抑制受体，该受体是P1 - 或更具体地说是A1 - 嘌呤受体。似乎没有必要假定存在一种新型的接头前P3 - 嘌呤受体。此外，交感神经末梢轴突在这两个物种中都具有一种额外的P2 - 嘌呤受体，该受体可被β,γ - 亚甲基 - ATP和2 - 甲硫基 - ATP等一些核苷酸激活，尽管在大鼠中很难证明β,γ - 亚甲基 - ATP对P2 - 嘌呤受体的激活作用。