苏拉明：小鼠输精管中的一种可逆性P2嘌呤受体拮抗剂。
Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.
作者信息
Dunn P M, Blakeley A G
机构信息
Department of Physiology, University of Leicester.
出版信息
Br J Pharmacol. 1988 Feb;93(2):243-5. doi: 10.1111/j.1476-5381.1988.tb11427.x.
Abstract
The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.
摘要
锥虫杀灭剂苏拉明作为小鼠输精管P2嘌呤受体的一种可能拮抗剂进行了测试。在100微摩尔浓度下，苏拉明拮抗了对α,β-亚甲基ATP的反应，而对卡巴胆碱和去甲肾上腺素的反应未受影响。这些结果表明，苏拉明可能为开发P2嘌呤受体的特异性拮抗剂提供一个起点。
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