Martínez-Piñeiro L, Mateos F, Montero A, Madero R, Martínez-Piñeiro J A
Department of Urology, La Paz Hospital, Madrid, Spain.
Br J Urol. 1993 Dec;72(6):851-7. doi: 10.1111/j.1464-410x.1993.tb16286.x.
This study was conducted to quantify urinary solute transport by the ileum, using an in vivo human model, and to determine the effect of nicotinic acid on this process. Patients were studied under both basal conditions and niacin therapy. The rates of solute transport were established by analysis of excretion indexes for each solute. Potassium and ammonium were absorbed by the ileum, while phosphorus, sodium and bicarbonate were secreted. The percentage excretion index of sodium and bicarbonate increased by approximately 100 and 600% respectively, causing a significant rise in urinary pH. Although not statistically significant, there was a tendency for chloride to be absorbed and for water to pass into the bowel lumen. Nicotinic acid 3 g/day had no significant effect on urinary solute transport.
本研究旨在利用人体活体模型对回肠的尿溶质转运进行定量分析，并确定烟酸对该过程的影响。对患者在基础条件和烟酸治疗两种情况下进行了研究。通过分析每种溶质的排泄指标来确定溶质转运速率。回肠吸收钾和铵，而分泌磷、钠和碳酸氢盐。钠和碳酸氢盐的排泄指数百分比分别增加了约100%和600%，导致尿液pH值显著升高。虽然无统计学意义，但氯有被吸收、水进入肠腔的趋势。每天3克烟酸对尿溶质转运无显著影响。
